Quality by design in the chiral separation strategy for the determination of enantiomeric impurities: development of a capillary electrophoresis method based on dual cyclodextrin systems for the analysis of levosulpiride.

Orlandini, S; Pasquini, B; Del Bubba, M; Pinzauti, S; Furlanetto, S

Orlandini, S; Pasquini, B; Del Bubba, M; Pinzauti, S; Furlanetto, S.

Afiliação

Orlandini S; Department of Chemistry "U. Schiff", University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
Pasquini B; Department of Chemistry "U. Schiff", University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
Del Bubba M; Department of Chemistry "U. Schiff", University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Florence, Italy.
Pinzauti S; Department of Chemistry "U. Schiff", University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
Furlanetto S; Department of Chemistry "U. Schiff", University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address: sandra.furlanetto@unifi.it.

J Chromatogr A ; 1380: 177-85, 2015 Feb 06.

Article em En | MEDLINE | ID: mdl-25582483

Assuntos

Antipsicóticos/isolamento & purificação; Ciclodextrinas/química; Eletroforese Capilar/métodos; Sulpirida/análogos & derivados; Método de Monte Carlo; Estereoisomerismo; Sulpirida/isolamento & purificação

Palavras-chave

Capillary electrophoresis; Chiral separation; Enantiomeric impurity; Experimental design; Levosulpiride; Quality by design

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulpirida / Antipsicóticos / Eletroforese Capilar / Ciclodextrinas Tipo de estudo: Health_economic_evaluation Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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