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Pyridodiazepine amines are selective therapeutic agents for helicobacter pylori by suppressing growth through inhibition of glutamate racemase but are predicted to require continuous elevated levels in plasma to achieve clinical efficacy.
de Jonge, Boudewijn L M; Kutschke, Amy; Newman, Joseph V; Rooney, Michael T; Yang, Wei; Cederberg, Christer.
Afiliação
  • de Jonge BL; Infection Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA boudewijn.dejonge@astrazeneca.com.
  • Kutschke A; Infection Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Newman JV; Infection Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Rooney MT; Infection DMPK, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Yang W; Infection Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Cederberg C; Cardiovascular Gastrointestinal Innovative Medicines Unit, AstraZeneca R&D Mölndal, Molndal, Sweden.
Antimicrob Agents Chemother ; 59(4): 2337-42, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25645840
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Azepinas / Helicobacter pylori / Infecções por Helicobacter / Isomerases de Aminoácido / Antibacterianos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Azepinas / Helicobacter pylori / Infecções por Helicobacter / Isomerases de Aminoácido / Antibacterianos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article