The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses.

Wolf, Gernot; Yang, Peng; Füchtbauer, Annette C; Füchtbauer, Ernst-Martin; Silva, Andreia M; Park, Chungoo; Wu, Warren; Nielsen, Anders L; Pedersen, Finn S; Macfarlan, Todd S

Wolf, Gernot; Yang, Peng; Füchtbauer, Annette C; Füchtbauer, Ernst-Martin; Silva, Andreia M; Park, Chungoo; Wu, Warren; Nielsen, Anders L; Pedersen, Finn S; Macfarlan, Todd S.

Afiliação

Wolf G; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892, USA; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark;
Yang P; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892, USA;
Füchtbauer AC; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark;
Füchtbauer EM; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark;
Silva AM; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark;
Park C; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892, USA;
Wu W; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892, USA;
Nielsen AL; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Pedersen FS; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark;
Macfarlan TS; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892, USA; todd.macfarlan@nih.gov.

Genes Dev ; 29(5): 538-54, 2015 Mar 01.

Article em En | MEDLINE | ID: mdl-25737282

Assuntos

Proteínas de Ligação a DNA/metabolismo; Retrovirus Endógenos/genética; Epigênese Genética; Inativação Gênica; Animais; Sítios de Ligação; Proteínas de Ligação a DNA/genética; Embrião de Mamíferos; Retrovirus Endógenos/fisiologia; Genoma; Histonas/metabolismo; Camundongos; Camundongos Knockout; Ligação Proteica; Ativação Viral/genética; Integração Viral/genética

Palavras-chave

KRAB zinc finger proteins; endogenous retrovirus; epigenetic silencing; retrovirus restriction factors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retrovirus Endógenos / Inativação Gênica / Epigênese Genética / Proteínas de Ligação a DNA Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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