Efficient asymmetric synthesis of structurally diverse P-stereogenic phosphinamides for catalyst design.
Angew Chem Int Ed Engl
; 54(18): 5474-7, 2015 Apr 27.
Article
em En
| MEDLINE
| ID: mdl-25757595
ABSTRACT
The use of chiral phosphinamides is relatively unexplored because of the lack of a general method for the synthesis. Reported herein is the development of a general, efficient, and highly enantioselective method for the synthesis of structurally diverse P-stereogenic phosphinamides. The method relies on nucleophilic substitution of a chiral phosphinate derived from the versatile chiral phosphinyl transfer agent 1,3,2-benzoxazaphosphinine-2-oxide. These chiral phosphinamides were utilized for the first synthesis of readily tunable P-stereogenic Lewis base organocatalysts, which were used successfully for highly enantioselective catalysis.
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MEDLINE
Assunto principal:
Fosfinas
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Ácidos Fosfínicos
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Bases de Lewis
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Amidas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article