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Recent advances in the chemistry and biology of pyridopyrimidines.
Buron, F; Mérour, J Y; Akssira, M; Guillaumet, G; Routier, S.
Afiliação
  • Buron F; Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France.
  • Mérour JY; Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France.
  • Akssira M; Équipe de Chimie Bioorganique & Analytique, URAC 22, Université Hassan II Mohammedia-Casablanca, BP 146, 28800 Mohammedia, Morocco.
  • Guillaumet G; Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France.
  • Routier S; Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France. Electronic address: sylvain.routier@univ-orleans.fr.
Eur J Med Chem ; 95: 76-95, 2015 May 05.
Article em En | MEDLINE | ID: mdl-25794791
The interest in pyridopyrimidine cores for pharmaceutical products makes this scaffold a highly useful building block for organic chemistry. These derivatives have found applications in various areas of medicine such as anticancer, CNS, fungicidal, antiviral, anti-inflammatory, antimicrobial, and antibacterial therapies. This review mainly focuses on the progress achieved since 2004 in the chemistry and biological activity of pyridopyrimidines.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Pirimidinas / Fármacos do Sistema Nervoso Central / Compostos Heterocíclicos / Anti-Infecciosos / Anti-Inflamatórios / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Pirimidinas / Fármacos do Sistema Nervoso Central / Compostos Heterocíclicos / Anti-Infecciosos / Anti-Inflamatórios / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article