Malaria parasites produce volatile mosquito attractants.
mBio
; 6(2)2015 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-25805727
ABSTRACT
UNLABELLED The malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid organelle that possesses plant-like metabolic pathways. Plants use the plastidial isoprenoid biosynthesis pathway to produce volatile odorants, known as terpenes. In this work, we describe the volatile chemical profile of cultured malaria parasites. Among the identified compounds are several plant-like terpenes and terpene derivatives, including known mosquito attractants. We establish the molecular identity of the odorant receptors of the malaria mosquito vector Anopheles gambiae, which responds to these compounds. The malaria parasite produces volatile signals that are recognized by mosquitoes and may thereby mediate host attraction and facilitate transmission. IMPORTANCE Malaria is a key global health concern. Mosquitoes that transmit malaria are more attracted to malaria parasite-infected mammalian hosts. These studies aimed to understand the chemical signals produced by malaria parasites; such an understanding may lead to new transmission-blocking strategies or noninvasive malaria diagnostics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Feromônios
/
Plasmodium
/
Compostos Orgânicos Voláteis
/
Anopheles
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article