Discovery of a Small-Molecule Probe for V-ATPase Function.
J Am Chem Soc
; 137(16): 5563-8, 2015 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-25860544
ABSTRACT
Lysosomes perform a critical cellular function as a site of degradation for diverse cargoes including proteins, organelles, and pathogens delivered through distinct pathways, and defects in lysosomal function have been implicated in a number of diseases. Recent studies have elucidated roles for the lysosome in the regulation of protein synthesis, metabolism, membrane integrity, and other processes involved in homeostasis. Complex small-molecule natural products have greatly contributed to the investigation of lysosomal function in cellular physiology. Here we report the discovery of a novel, small-molecule modulator of lysosomal acidification derived from diversity-oriented synthesis through high-content screening.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
ATPases Vacuolares Próton-Translocadoras
/
Inibidores Enzimáticos
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Bibliotecas de Moléculas Pequenas
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Lisossomos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article