Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.

Zhao, Peishen; Lieu, TinaMarie; Barlow, Nicholas; Sostegni, Silvia; Haerteis, Silke; Korbmacher, Christoph; Liedtke, Wolfgang; Jimenez-Vargas, Nestor N; Vanner, Stephen J; Bunnett, Nigel W

Zhao, Peishen; Lieu, TinaMarie; Barlow, Nicholas; Sostegni, Silvia; Haerteis, Silke; Korbmacher, Christoph; Liedtke, Wolfgang; Jimenez-Vargas, Nestor N; Vanner, Stephen J; Bunnett, Nigel W.

Afiliação

Zhao P; From the Monash Institute of Pharmaceutical Sciences and.
Lieu T; From the Monash Institute of Pharmaceutical Sciences and.
Barlow N; From the Monash Institute of Pharmaceutical Sciences and.
Sostegni S; the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91054, Germany.
Haerteis S; the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91054, Germany.
Korbmacher C; the Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91054, Germany.
Liedtke W; the Department of Neurology, School of Medicine, Duke University, Durham, North Carolina 27710.
Jimenez-Vargas NN; the Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, Ontario N7L 3N6, Canada, and.
Vanner SJ; the Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, Ontario N7L 3N6, Canada, and.
Bunnett NW; From the Monash Institute of Pharmaceutical Sciences and the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville 3052, Australia, the Department of Pharmacology, University of Melbourne, Melbourne 3010, Australia Nigel.Bunnett@Monash.edu.

J Biol Chem ; 290(22): 13875-87, 2015 May 29.

Article em En | MEDLINE | ID: mdl-25878251

Assuntos

Inflamação/metabolismo; Elastase de Leucócito/metabolismo; Dor/metabolismo; Receptor PAR-2/metabolismo; Canais de Cátion TRPV/metabolismo; Animais; Cálcio/metabolismo; Membrana Celular/metabolismo; AMP Cíclico/metabolismo; Edema/metabolismo; Edema/patologia; Proteínas de Ligação ao GTP/metabolismo; Gânglios Espinais/metabolismo; Células HEK293; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Neurônios/metabolismo; Nociceptividade; Oócitos/citologia; Oócitos/metabolismo; Técnicas de Patch-Clamp; Peptídeo Hidrolases/metabolismo; Estrutura Terciária de Proteína; Transdução de Sinais; Xenopus laevis/metabolismo

Palavras-chave

G protein-coupled receptor (GPCR); biased agonism; cell signaling; inflammation; nociception; protease; protease-activated receptor; transient receptor potential channels (TRP channels)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Elastase de Leucócito / Receptor PAR-2 / Canais de Cátion TRPV / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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