Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells.
Nat Immunol
; 16(6): 663-73, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25894659
ABSTRACT
When B cells encounter an antigen, they alter their physiological state and anatomical localization and initiate a differentiation process that ultimately produces antibody-secreting cells (ASCs). We have defined the transcriptomes of many mature B cell populations and stages of plasma cell differentiation in mice. We provide a molecular signature of ASCs that highlights the stark transcriptional divide between B cells and plasma cells and enables the demarcation of ASCs on the basis of location and maturity. Changes in gene expression correlated with cell-division history and the acquisition of permissive histone modifications, and they included many regulators that had not been previously implicated in B cell differentiation. These findings both highlight and expand the core program that guides B cell terminal differentiation and the production of antibodies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
/
Diferenciação Celular
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Transcriptoma
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article