Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.

Razidlo, Gina L; Magnine, Christopher; Sletten, Arthur C; Hurley, Rachel M; Almada, Luciana L; Fernandez-Zapico, Martin E; Ji, Baoan; McNiven, Mark A

Razidlo, Gina L; Magnine, Christopher; Sletten, Arthur C; Hurley, Rachel M; Almada, Luciana L; Fernandez-Zapico, Martin E; Ji, Baoan; McNiven, Mark A.

Afiliação

Razidlo GL; Center for Basic Research in Digestive Diseases, Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
Magnine C; Center for Basic Research in Digestive Diseases, Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota.
Sletten AC; Center for Basic Research in Digestive Diseases, Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota.
Hurley RM; Mayo Graduate School, Mayo Clinic, Rochester, Minnesota.
Almada LL; Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota.
Fernandez-Zapico ME; Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota.
Ji B; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
McNiven MA; Center for Basic Research in Digestive Diseases, Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota. mcniven.mark@mayo.edu.

Cancer Res ; 75(14): 2907-15, 2015 Jul 15.

Article em En | MEDLINE | ID: mdl-25977335

Assuntos

Adenocarcinoma/tratamento farmacológico; Adenocarcinoma/patologia; Antineoplásicos/uso terapêutico; Azatioprina/uso terapêutico; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/patologia; Proteínas Proto-Oncogênicas c-vav/antagonistas & inibidores; Adenocarcinoma/genética; Animais; Feminino; Humanos; Camundongos; Camundongos Nus; Camundongos Transgênicos; Terapia de Alvo Molecular/métodos; Invasividade Neoplásica; Metástase Neoplásica; Neoplasias Pancreáticas/genética; Proteínas Proto-Oncogênicas c-vav/genética; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Azatioprina / Adenocarcinoma / Proteínas Proto-Oncogênicas c-vav / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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