Investigating a Relationship between the Mutagenicity of Arylboronic Acids and (11)B NMR Chemical Shifts.
Chem Res Toxicol
; 28(7): 1422-6, 2015 Jul 20.
Article
em En
| MEDLINE
| ID: mdl-26018175
ABSTRACT
The mutagenicity of arylboronic acids has recently become an important area of research because of their potential to be genotoxic impurities in active pharmaceutical ingredients. There is no known mechanism, so currently all structure-activity relationships have been derived using Ames test data. We present preliminary data supporting a hypothesis that the mutagenicity of arylboronic acids is related to the (11)B NMR chemical shift. This could indicate that the mutagenic activity of the arylboronic acids is related to the reactivity of the boron center.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Borônicos
/
Espectroscopia de Ressonância Magnética
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article