A novel peptide-based recognition probe for the sensitive detection of CD44 on breast cancer stem cells.
Mol Cell Probes
; 29(6): 492-499, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26038340
ABSTRACT
Metastasis and recurrence of breast cancer remain significant clinical problems. The expression level of CD44 protein is higher in breast cancer-initiating cancer stem cells; therefore, the early detection of CD44 using a sensitive diagnostic probe is important for breast cancer diagnosis and therapeutic purposes. In this study, we fabricated a polyvalent directed peptide polymer (PDPP) that specifically recognized the CD44 biomarker, as confirmed by immunocytochemistry tests and fluorescence-activated cell sorting assessment. Our results indicate that PDPP is useful as a novel tool for the sensitive detection of breast cancer stem cells.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Células-Tronco Neoplásicas
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Neoplasias da Mama
/
Receptores de Hialuronatos
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article