A new and efficient synthesis of 6-O-methylscutellarein, the major metabolite of the natural medicine scutellarin.
Molecules
; 20(6): 10184-91, 2015 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-26042857
ABSTRACT
In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at C-4' and C-7 in 2 were selectively protected by chloromethyl methyl ether after the reaction conditions were optimized, then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups.
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Base de dados:
MEDLINE
Assunto principal:
Flavonas
/
Apigenina
/
Glucuronatos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article