Histone variants as emerging regulators of embryonic stem cell identity.
Epigenetics
; 10(7): 563-73, 2015.
Article
em En
| MEDLINE
| ID: mdl-26114724
ABSTRACT
Dynamic regulation of chromatin structure is an important mechanism for balancing the pluripotency and cell fate decision in embryonic stem cells (ESCs). Indeed ESCs are characterized by unusual chromatin packaging, and a wide variety of chromatin regulators have been implicated in control of pluripotency and differentiation. Genome-wide maps of epigenetic factors have revealed a unique epigenetic signature in pluripotent ESCs and have contributed models to explain their plasticity. In addition to the well known epigenetic regulation through DNA methylation, histone posttranslational modifications, chromatin remodeling, and non-coding RNA, histone variants are emerging as important regulators of ESC identity. In this review, we summarize and discuss the recent progress that has highlighted the central role of histone variants in ESC pluripotency and ESC fate, focusing, in particular, on H1 variants, H2A variants H2A.X, H2A.Z and macroH2A and H3 variant H3.3.
Palavras-chave
ChIP-seq, Chromatin Immunoprecipitation Sequencing; EB, embryoid body; EHP cells, endoderm/hepatic progenitor cells; ESCs, embryonic stem cells; MEFs, mouse embryonic fibroblasts; NLBs, nucleolar-like bodies; PcG, Polycomb group; TSS, transcription start site; chromatin dynamics; embryonic stem cell; histone variant; iPSCs, induced pluripotent stem cells; pluripotency; self-renewal
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Código das Histonas
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Células-Tronco Embrionárias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article