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Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.
Veldkamp, Christopher T; Kiermaier, Eva; Gabel-Eissens, Skylar J; Gillitzer, Miranda L; Lippner, David R; DiSilvio, Frank A; Mueller, Casey J; Wantuch, Paeton L; Chaffee, Gary R; Famiglietti, Michael W; Zgoba, Danielle M; Bailey, Asha A; Bah, Yaya; Engebretson, Samantha J; Graupner, David R; Lackner, Emily R; LaRosa, Vincent D; Medeiros, Tysha; Olson, Michael L; Phillips, Andrew J; Pyles, Harley; Richard, Amanda M; Schoeller, Scott J; Touzeau, Boris; Williams, Larry G; Sixt, Michael; Peterson, Francis C.
Afiliação
  • Veldkamp CT; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Kiermaier E; ‡Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
  • Gabel-Eissens SJ; §IST Austria (Institute for Science and Technology Austria), 3400 Klosterneuburg, Austria.
  • Gillitzer ML; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Lippner DR; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • DiSilvio FA; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Mueller CJ; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Wantuch PL; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Chaffee GR; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Famiglietti MW; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Zgoba DM; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Bailey AA; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Bah Y; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Engebretson SJ; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Graupner DR; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Lackner ER; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • LaRosa VD; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Medeiros T; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Olson ML; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Phillips AJ; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Pyles H; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Richard AM; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Schoeller SJ; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Touzeau B; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Williams LG; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Sixt M; †Department of Chemistry, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, Wisconsin 53190, United States.
  • Peterson FC; §IST Austria (Institute for Science and Technology Austria), 3400 Klosterneuburg, Austria.
Biochemistry ; 54(27): 4163-6, 2015 Jul 14.
Article em En | MEDLINE | ID: mdl-26115234
CCL19 and CCL21 are chemokines involved in the trafficking of immune cells, particularly within the lymphatic system, through activation of CCR7. Concurrent expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells to secondary lymphoid organs by CCL19 and CCL21. Here the solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive. Implications for the mechanism of PSGL-1's enhancement of resting T-cell recruitment are discussed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Quimiocina CCL19 / Receptores CCR7 Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Quimiocina CCL19 / Receptores CCR7 Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article