Role of cyclins D1 and D3 in vestibular schwannoma.
J Laryngol Otol
; 130 Suppl 1: S2-10, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26165351
ABSTRACT
BACKGROUND:
Vestibular schwannomas in younger patients have been observed to be larger in size and grow more quickly.OBJECTIVE:
This study aimed to evaluate the expression of three important cell cycle proteins, cyclin D1, cyclin D3 and Ki-67, in vestibular schwannoma patients separated into two age groups ≤ 40 years or > 40 years.METHOD:
Immunohistochemical detection of cyclin D1, cyclin D3 and Ki-67 was undertaken in 180 surgically resected vestibular schwannomas.RESULTS:
The proliferation index of vestibular schwannomas was statistically higher in the ≤ 40 years age group compared to that in the > 40 years age group (mean of 4.52 vs 3.27, respectively; p = 0.01). Overexpression of cyclin D1 and cyclin D3 was found in 68 per cent and 44 per cent of tumours, respectively.CONCLUSION:
There was an increased Ki-67 proliferation index in the younger age group that appears to correlate with clinical behaviour. Vestibular schwannomas in both age groups show increased expression of cyclin D1 and cyclin D3.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neuroma Acústico
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Antígeno Ki-67
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Ciclina D1
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Ciclina D3
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Proteínas de Neoplasias
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article