Molecular Property Design: Does Everyone Get It?
ACS Med Chem Lett
; 6(7): 722-5, 2015 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-26191353
ABSTRACT
The principles of molecular property optimization in drug design have been understood for decades, yet much drug discovery activity today is conducted at the periphery of historical druglike property space. Lead optimization trajectories aimed at reducing physicochemical risk, assisted by ligand efficiency metrics, could help to reduce clinical attrition rates.
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MEDLINE
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En
Ano de publicação:
2015
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Article