Effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis.
Eur Rev Med Pharmacol Sci
; 19(14): 2646-50, 2015.
Article
em En
| MEDLINE
| ID: mdl-26221896
ABSTRACT
OBJECTIVE:
To investigate the effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis (SAP). MATERIALS ANDMETHODS:
Ninety male Wistar rats were randomly divided into a blank control group, an SAP group and a vascular bradykinin treatment group. The SAP model was induced by the retrograde injection of 5% sodium taurocholate in the pancreaticobiliary duct. The vascular bradykinin treatment group underwent gastrostomy, with a fine plastic tube placed in the stomach that led out of body through the abdominal wall.Vascular bradykinin was fully dissolved and administered at a dose of 20 U/kg once every 8 h. The pancreatic microcirculatory blood flow volume and velocity, microvascular permeability, hemorheology were evaluated respectively by double-channel laser Doppler flowmetry, the Evans blue leakage test, a blood rheology test instrument.RESULTS:
The pancreatic microcirculatory blood flow volume and velocity in the vascular bradykinin treatment group increased gradually after 48 h compared with the SAP group, and the changes were significantly different (p < 0.05). The pancreatic microvascular permeability of the vascular bradykinin treatment group was significantly reduced after 48 h compared with the SAP group (p < 0.05). The low shear rate blood viscosity, hematocrit and erythrocyte aggregation index of the vascular bradykinin treatment group were significantly decreased after 48 h compared with the SAP group (p < 0.05).CONCLUSIONS:
Vascular bradykinin can improve pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis.
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Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Pancreatite
/
Índice de Gravidade de Doença
/
Bradicinina
/
Hemorreologia
/
Microcirculação
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article