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The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors.
Stec, Markian M; Andrews, Kristin L; Bo, Yunxin; Caenepeel, Sean; Liao, Hongyu; McCarter, John; Mullady, Erin L; San Miguel, Tisha; Subramanian, Raju; Tamayo, Nuria; Whittington, Douglas A; Wang, Ling; Wu, Tian; Zalameda, Leeanne P; Zhang, Nancy; Hughes, Paul E; Norman, Mark H.
Afiliação
  • Stec MM; Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA. Electronic address: mstec@amgen.com.
  • Andrews KL; Department of Molecular Structure, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Bo Y; Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Caenepeel S; Department of Oncology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Liao H; Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • McCarter J; Department of High-Throughput Screening/Molecular Pharmacology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Mullady EL; Department of High-Throughput Screening/Molecular Pharmacology, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, USA.
  • San Miguel T; Department of High-Throughput Screening/Molecular Pharmacology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Subramanian R; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Tamayo N; Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Whittington DA; Department of Molecular Structure, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA.
  • Wang L; Department of Oncology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Wu T; Department of Basic Pharmaceutics, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Zalameda LP; Department of High-Throughput Screening/Molecular Pharmacology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Zhang N; Department of Oncology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Hughes PE; Department of Oncology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Norman MH; Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
Bioorg Med Chem Lett ; 25(19): 4136-42, 2015 Oct 01.
Article em En | MEDLINE | ID: mdl-26298499
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article