A guide to genome-wide association analysis and post-analytic interrogation.

Reed, Eric; Nunez, Sara; Kulp, David; Qian, Jing; Reilly, Muredach P; Foulkes, Andrea S

Reed, Eric; Nunez, Sara; Kulp, David; Qian, Jing; Reilly, Muredach P; Foulkes, Andrea S.

Afiliação

Reed E; Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA, U.S.A.
Nunez S; Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA, U.S.A.
Kulp D; Department of Computer Science, University of Massachusetts, Amherst, MA, U.S.A.
Qian J; Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, U.S.A.
Reilly MP; Department of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Foulkes AS; Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA, U.S.A.

Stat Med ; 34(28): 3769-92, 2015 Dec 10.

Article em En | MEDLINE | ID: mdl-26343929

Assuntos

Biologia Computacional; Estudo de Associação Genômica Ampla; Bases de Dados Genéticas; Estudo de Associação Genômica Ampla/estatística & dados numéricos; Humanos; Software

Palavras-chave

Bioconductor; Hardy-Weinberg equilibrium (HWE); IBD; Manhattan plot; Q-Q plot; R code; SNP filtering; UCSC Genome Browser; ancestry; call rate; genome-wide association (GWA) study; heatmap; heterozygosity; imputation; lambda statistic; minor allele frequency (MAF); parallel processing; principal component analysis (PCA); regional association plot; relatedness; sample filtering; statistical genomics; substructure; tutorial

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biologia Computacional / Estudo de Associação Genômica Ampla Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google