Developing Anticancer Copper(II) Pro-drugs Based on the Nature of Cancer Cells and the Human Serum Albumin Carrier IIA Subdomain.

Gou, Yi; Qi, Jinxu; Ajayi, Joshua-Paul; Zhang, Yao; Zhou, Zuping; Wu, Xiaoyang; Yang, Feng; Liang, Hong

Gou, Yi; Qi, Jinxu; Ajayi, Joshua-Paul; Zhang, Yao; Zhou, Zuping; Wu, Xiaoyang; Yang, Feng; Liang, Hong.

Afiliação

Gou Y; State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China. Guangxi Normal University , Guilin, Guangxi, China.
Qi J; State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China. Guangxi Normal University , Guilin, Guangxi, China.
Ajayi JP; Ben May Department for Cancer Research, University of Chicago , Chicago, Illinois 60637, United States.
Zhang Y; State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China. Guangxi Normal University , Guilin, Guangxi, China.
Zhou Z; Guangxi Universities Key Laboratory of Stem Cell and Pharmaceutical Biotechnology, Guangxi Normal University , Guilin, Guangxi, China.
Wu X; Ben May Department for Cancer Research, University of Chicago , Chicago, Illinois 60637, United States.
Yang F; State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China. Guangxi Normal University , Guilin, Guangxi, China.
Liang H; State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China. Guangxi Normal University , Guilin, Guangxi, China.

Mol Pharm ; 12(10): 3597-609, 2015 Oct 05.

Article em En | MEDLINE | ID: mdl-26354410

Assuntos

Antineoplásicos/uso terapêutico; Cobre/uso terapêutico; Neoplasias/tratamento farmacológico; Pró-Fármacos/uso terapêutico; Albumina Sérica/metabolismo; Apoptose/efeitos dos fármacos; Western Blotting; Cristalografia por Raios X; Sistemas de Liberação de Medicamentos/métodos; Descoberta de Drogas/métodos; Citometria de Fluxo; Humanos; Células MCF-7/efeitos dos fármacos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Espécies Reativas de Oxigênio/metabolismo; Albumina Sérica/química; Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz

Palavras-chave

anticancer activity; anticancer mechanism; drug delivery systems; human serum albumin; pro-drug

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Albumina Sérica / Pró-Fármacos / Cobre / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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