Strengths and weaknesses of methods for identifying monoclonal free light chains of Ig: examples from two cases with renal disease.
Clin Chem Lab Med
; 54(6): 1039-43, 2016 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-26368046
ABSTRACT
BACKGROUND:
Serum free light chain (FLC) analysis with ratio and urine immunofixation electrophoresis (IFE) are both available for routine use in helping to detect plasma cell dyscrasia and related diseases. CASES Case reports showing one serum positive for serum FLC but that showed a hook effect and overestimated the amount of monoclonal FLC while urine IFE was negative for Bence Jones protein, and a second serum that showed elevated FLC κ and λ but a normal κ/λ ratio, while urine IFE was positive for Bence Jones protein.CONCLUSIONS:
These two techniques complement one another. Neither of the techniques is truly quantitative, and both exhibit methodological defects.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paraproteinemias
/
Eletroforese das Proteínas Sanguíneas
/
Cadeias Leves de Imunoglobulina
/
Insuficiência Renal
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Aged
/
Aged80
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article