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1,4-Oxazine ß-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.
Rombouts, Frederik J R; Tresadern, Gary; Delgado, Oscar; Martínez-Lamenca, Carolina; Van Gool, Michiel; García-Molina, Aránzazu; Alonso de Diego, Sergio A; Oehlrich, Daniel; Prokopcova, Hana; Alonso, José Manuel; Austin, Nigel; Borghys, Herman; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Alexander, Richard; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie; Trabanco, Andrés A.
Afiliação
  • Rombouts FJ; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Tresadern G; Discovery Sciences, Janssen Research & Development, Janssen-Cilag SA , C/Jarama 75A, 45007 Toledo, Spain.
  • Delgado O; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag SA , C/Jarama 75A, 45007 Toledo, Spain.
  • Martínez-Lamenca C; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Van Gool M; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag SA , C/Jarama 75A, 45007 Toledo, Spain.
  • García-Molina A; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag SA , C/Jarama 75A, 45007 Toledo, Spain.
  • Alonso de Diego SA; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag SA , C/Jarama 75A, 45007 Toledo, Spain.
  • Oehlrich D; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Prokopcova H; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Alonso JM; Discovery Sciences, Janssen Research & Development, Janssen-Cilag SA , C/Jarama 75A, 45007 Toledo, Spain.
  • Austin N; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Borghys H; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Van Brandt S; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Surkyn M; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • De Cleyn M; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Vos A; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Alexander R; Biologics Research, Janssen Research & Development , 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
  • Macdonald G; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Moechars D; Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Gijsen H; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Trabanco AA; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag SA , C/Jarama 75A, 45007 Toledo, Spain.
J Med Chem ; 58(20): 8216-35, 2015 Oct 22.
Article em En | MEDLINE | ID: mdl-26378740
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxazinas / Encéfalo / Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxazinas / Encéfalo / Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article