X-ray recordings reveal how a human disease-linked skeletal muscle &#945;-actin mutation leads to contractile dysfunction.

Ochala, Julien; Ravenscroft, Gianina; McNamara, Elyshia; Nowak, Kristen J; Iwamoto, Hiroyuki

X-ray recordings reveal how a human disease-linked skeletal muscle α-actin mutation leads to contractile dysfunction.

Ochala, Julien; Ravenscroft, Gianina; McNamara, Elyshia; Nowak, Kristen J; Iwamoto, Hiroyuki.

Afiliação

Ochala J; Centre of Human and Aerospace Physiological Sciences, School of Biomedical Sciences, King's College London, London, United Kingdom. Electronic address: julien.ochala@kcl.ac.uk.
Ravenscroft G; Harry Perkins Institute of Medical Research, The University of Western Australia, Nedlands, Australia.
McNamara E; Harry Perkins Institute of Medical Research, The University of Western Australia, Nedlands, Australia.
Nowak KJ; Harry Perkins Institute of Medical Research, The University of Western Australia, Nedlands, Australia.
Iwamoto H; Japan Synchrotron Radiation Research Institute, SPring8, Hyogo, Japan.

J Struct Biol ; 192(3): 331-335, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26407659

Assuntos

Actinas/genética; Contração Muscular/genética; Debilidade Muscular/genética; Músculo Esquelético/patologia; Miosinas/metabolismo; Tropomiosina/metabolismo; Substituição de Aminoácidos/genética; Animais; Humanos; Camundongos; Camundongos Transgênicos; Mutação; Miofibrilas/metabolismo; Difração de Raios X

Palavras-chave

Actin; Muscle disease; Myosin; Small-angle X-ray scattering

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tropomiosina / Actinas / Miosinas / Músculo Esquelético / Debilidade Muscular / Contração Muscular Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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