Human Retinal Pigment Epithelium Stem Cell (RPESC).
Adv Exp Med Biol
; 854: 557-62, 2016.
Article
em En
| MEDLINE
| ID: mdl-26427459
ABSTRACT
The retinal pigment epithelium (RPE) is a pigmented cellular monolayer that supports photoreceptor cells located in the overlying neural retina. The RPE is critical for vision and its dysfunction results in numerous pathologies, several with limited available disease-altering strategies. Regeneration of the retina from RPE is robust in lower vertebrates, but is not normally exhibited in mammals. We recently found that a subpopulation of human RPE cells can be stimulated in culture to generate multipotent self-renewing cells-the RPE stem cell (RPESC). RPESC can be expanded to generate RPE progeny that are a potential source for cell replacement therapy. Alternatively, RPESC can produce mesenchymal progeny which serve as a disease model of epiretinal membrane formation. Yet another potential application of RPESCs is activation within the eye to awaken dormant endogenous repair.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
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Diferenciação Celular
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Proliferação de Células
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Epitélio Pigmentado da Retina
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article