In Vitro Safety/Protection Assessment of Resveratrol and Pterostilbene in a Human Hepatoma Cell Line (HepG2).
Nat Prod Commun
; 10(8): 1403-8, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26434128
ABSTRACT
The aim of this work was to evaluate in vitro the genotoxic and/or antigenotoxic effects of resveratrol (RESV) and pterostilbene (PTER) on HepG2 cells. Moreover, additional tests were performed to evaluate early and late apoptosis events induced by the tested stilbenes. RESV and PTER did not show any genotoxic activity. As regards antigenotoxicity testing, RESV and PTER showed a typical, U-shaped hormetic dose-response relationship characterized by a biphasic trend with small quantities having opposite effects to large ones. HepG2 cells treated with PTER exhibited a marked increase in early apoptosis (40.1%) at 250 microM; whereas, the highest concentration tested for both RESV and PTER significantly increased the proportion of HepG2 cells undergoing late apoptosis (32.5 and 51.2%, respectively). The observed pro-apoptotic activity could, at least in part, explain the hormetic response observed when the compounds were tested for antigenotoxicity (i.e., in the presence of induced DNA damage).
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Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Carcinoma Hepatocelular
/
Substâncias Protetoras
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article