Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation.

Pariente, Roberto; Pariente, José A; Rodríguez, Ana B; Espino, Javier

Pariente, Roberto; Pariente, José A; Rodríguez, Ana B; Espino, Javier.

Afiliação

Pariente R; Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, Badajoz, Spain.
Pariente JA; Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, Badajoz, Spain.
Rodríguez AB; Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, Badajoz, Spain.
Espino J; Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, Badajoz, Spain.

J Pineal Res ; 60(1): 55-64, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26462739

Assuntos

Apoptose/efeitos dos fármacos; Cisplatino/farmacologia; Citotoxinas/farmacologia; Fragmentação do DNA/efeitos dos fármacos; DNA de Neoplasias/metabolismo; Melatonina/farmacologia; Estresse Oxidativo/efeitos dos fármacos; Neoplasias do Colo do Útero/tratamento farmacológico; Cisplatino/agonistas; Citotoxinas/agonistas; Feminino; Células HeLa; Humanos; Melatonina/agonistas; Neoplasias do Colo do Útero/metabolismo; Neoplasias do Colo do Útero/patologia

Palavras-chave

apoptosis; cervical cancer; chemotherapy; melatonin; oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA de Neoplasias / Neoplasias do Colo do Útero / Cisplatino / Apoptose / Estresse Oxidativo / Citotoxinas / Fragmentação do DNA / Melatonina Limite: Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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