Metabolic profiling of a novel antithrombotic compound, S002-333 and enantiomers: metabolic stability, species comparison and in vitro-in vivo extrapolation.

Saxena, Amrita; Valicherla, Guru R; Jain, Girish K; Bhatta, Rabi S; Saxena, Anil K; Gayen, Jiaur R

Saxena, Amrita; Valicherla, Guru R; Jain, Girish K; Bhatta, Rabi S; Saxena, Anil K; Gayen, Jiaur R.

Afiliação

Saxena A; Pharmacokinetics and Metabolism Division, CSIR - Central Drug Research Institute, Lucknow, 226031, India.
Valicherla GR; Pharmacokinetics and Metabolism Division, CSIR - Central Drug Research Institute, Lucknow, 226031, India.
Jain GK; Pharmacokinetics and Metabolism Division, CSIR - Central Drug Research Institute, Lucknow, 226031, India.
Bhatta RS; Pharmacokinetics and Metabolism Division, CSIR - Central Drug Research Institute, Lucknow, 226031, India.
Saxena AK; Medicinal and Processing Chemistry Division, CSIR - Central Drug Research Institute, Lucknow, 226031, India.
Gayen JR; Pharmacokinetics and Metabolism Division, CSIR - Central Drug Research Institute, Lucknow, 226031, India.

Biopharm Drug Dispos ; 37(4): 185-99, 2016 May.

Article em En | MEDLINE | ID: mdl-26477787

Assuntos

Carbolinas/metabolismo; Fibrinolíticos/metabolismo; Microssomos Hepáticos/metabolismo; Sulfonamidas/metabolismo; Animais; Carbolinas/química; Cães; Feminino; Fibrinolíticos/química; Humanos; Macaca mulatta; Masculino; Metaboloma; Coelhos; Ratos Sprague-Dawley; Especificidade da Espécie; Estereoisomerismo; Sulfonamidas/química

Palavras-chave

chiral inversion; in vitro-in vivo extrapolation; intrinsic clearance; metabolic stability; protein binding

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Microssomos Hepáticos / Carbolinas / Fibrinolíticos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google