Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates.
Q Rev Biophys
; 48(4): 389-94, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26537396
ABSTRACT
To date, most antibodies from combinatorial libraries have been selected purely on the basis of binding. However, new methods now allow selection on the basis of function in animal cells. These selected agonist antibodies have given new insights into the important problem of signal transduction. Remarkably, when some antibodies bind to a given receptor they induce a cell fate that is different than that induced by the natural agonist to the same receptor. The fact that receptors can be functionally pleiotropic may yield new insights into the important problem of signal transduction.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Linhagem da Célula
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Técnicas de Química Combinatória
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Anticorpos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article