Abnormal short-latency synaptic plasticity in the motor cortex of subjects with Becker muscular dystrophy: a rTMS study.
Neurosci Lett
; 610: 218-22, 2016 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-26562314
ABSTRACT
We used repetitive transcranial magnetic stimulation (rTMS) to further investigate motor cortex excitability in 13 patients with Becker muscular dystrophy (BMD), six of them with slight mental retardation. RTMS delivered at 5Hz frequency and suprathreshold intensity progressively increases the size of motor evoked potentials (MEPs) in healthy subjects; the rTMS-induced facilitation of MEPs was significantly reduced in the BMD patients mentally retarded or classified as borderline when compared with age-matched control subjects and the BMD patients with normal intelligence. The increase in the duration of the cortical silent period was similar in both patient groups and controls. These findings suggest an altered cortical short-term synaptic plasticity in glutamate-dependent excitatory circuits within the motor cortex in BMD patients with intellectual disabilities. RTMS studies may shed new light on the physiological mechanisms of cortical involvement in dystrophinopathies.
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Base de dados:
MEDLINE
Assunto principal:
Distrofia Muscular de Duchenne
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Estimulação Magnética Transcraniana
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Córtex Motor
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Plasticidade Neuronal
Tipo de estudo:
Observational_studies
Limite:
Adolescent
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Adult
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article