B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform To Generate Antigen-Specific Helper T Cells for Cell Therapy.
Nano Lett
; 16(1): 297-308, 2016 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-26650819
ABSTRACT
Adoptive cell therapy represents a promising approach for several chronic diseases. This study describes an innovative strategy for biofunctionalization of nanoparticles, allowing the generation of synthetic particulate antigens (SPAg). SPAg activate polyclonal B cells and vectorize noncognate proteins into their endosomes, generating highly efficient stimulators for ex vivo expansion of antigen-specific CD4+ T cells. This method also allows harnessing the ability of B cells to polarize CD4+ T cells into effectors or regulators.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas Sintéticas
/
Imunoterapia Adotiva
/
Nanopartículas
/
Terapia Baseada em Transplante de Células e Tecidos
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article