Inhibition of cyclic AMP response element-directed transcription by decoy oligonucleotides enhances tumor-specific radiosensitivity.

Park, Serk In; Park, Sung-Jun; Lee, Junghan; Kim, Hye Eun; Park, Su Jin; Sohn, Jeong-Won; Park, Yun Gyu

Park, Serk In; Park, Sung-Jun; Lee, Junghan; Kim, Hye Eun; Park, Su Jin; Sohn, Jeong-Won; Park, Yun Gyu.

Afiliação

Park SI; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea; The BK21 Plus Program for Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea; Department of Medicine and Center for Bone Biology, Vanderbilt University S
Park SJ; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea; Laboratory of Obesity and Aging Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Lee J; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea.
Kim HE; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea.
Park SJ; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea.
Sohn JW; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea.
Park YG; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address: parkyg@korea.ac.kr.

Biochem Biophys Res Commun ; 469(3): 363-9, 2016 Jan 15.

Article em En | MEDLINE | ID: mdl-26655813

Assuntos

Fatores Ativadores da Transcrição/metabolismo; Modulador de Elemento de Resposta do AMP Cíclico/metabolismo; Raios gama/uso terapêutico; Neoplasias Experimentais/patologia; Neoplasias Experimentais/radioterapia; Oligonucleotídeos/administração & dosagem; Fatores Ativadores da Transcrição/genética; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos da radiação; Modulador de Elemento de Resposta do AMP Cíclico/genética; Humanos; Neoplasias Experimentais/genética; Tolerância a Radiação/efeitos dos fármacos; Tolerância a Radiação/genética; Transcrição Gênica

Palavras-chave

Cyclic AMP response element; Decoy; Radiosensitization; p38 MAPK; Î³-Irradiation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Fatores Ativadores da Transcrição / Modulador de Elemento de Resposta do AMP Cíclico / Raios gama / Neoplasias Experimentais Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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