Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay.
Org Biomol Chem
; 14(5): 1559-63, 2016 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-26740124
ABSTRACT
During efforts to prepare the known compound , a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Degradação do RNAm Mediada por Códon sem Sentido
/
Compostos Heterocíclicos de 4 ou mais Anéis
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article