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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay.
Gotham, Victoria J B; Hobbs, Melanie C; Burgin, Ryan; Turton, David; Smythe, Carl; Coldham, Iain.
Afiliação
  • Gotham VJ; Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.
  • Hobbs MC; Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk.
  • Burgin R; Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk.
  • Turton D; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.
  • Smythe C; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.
  • Coldham I; Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk.
Org Biomol Chem ; 14(5): 1559-63, 2016 Feb 07.
Article em En | MEDLINE | ID: mdl-26740124
ABSTRACT
During efforts to prepare the known compound , a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Degradação do RNAm Mediada por Códon sem Sentido / Compostos Heterocíclicos de 4 ou mais Anéis Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Degradação do RNAm Mediada por Códon sem Sentido / Compostos Heterocíclicos de 4 ou mais Anéis Idioma: En Ano de publicação: 2016 Tipo de documento: Article