Differentiating the Effect of an Opioid Agonist on Cardiac Repolarization From µ-Receptor-mediated, Indirect Effects on the QT Interval: A Randomized, 3-way Crossover Study in Healthy Subjects.

Darpo, Borje; Zhou, Meijian; Bai, Stephen A; Ferber, Georg; Xiang, Qinfang; Finn, Andrew

Darpo, Borje; Zhou, Meijian; Bai, Stephen A; Ferber, Georg; Xiang, Qinfang; Finn, Andrew.

Afiliação

Darpo B; Karolinska Institute, Department of Clinical Sciences, Danderyd's Hospital, Division of Cardiovascular Medicine, Stockholm, Sweden; iCardiac Technologies, Rochester, New York. Electronic address: borje.darpo@telia.com.
Zhou M; iCardiac Technologies, Rochester, New York.
Bai SA; Endo Pharmaceuticals Inc, Malvern, Pennsylvania.
Ferber G; Statistik Georg Ferber GmbH, Riehen, Switzerland.
Xiang Q; Endo Pharmaceuticals Inc, Malvern, Pennsylvania.
Finn A; BioDelivery Sciences International, Raleigh, North Carolina.

Clin Ther ; 38(2): 315-26, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26749217

Assuntos

Buprenorfina/farmacologia; Fluoroquinolonas/farmacologia; Naltrexona/farmacologia; Adulto; Estudos Cross-Over; Método Duplo-Cego; Eletrocardiografia/efeitos dos fármacos; Feminino; Coração/efeitos dos fármacos; Frequência Cardíaca/efeitos dos fármacos; Humanos; Masculino; Moxifloxacina

Palavras-chave

QT prolongation; buprenorphine; naltrexone; opioids; thorough QT study; µ-receptor blockade

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Buprenorfina / Fluoroquinolonas / Naltrexona Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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