Your browser doesn't support javascript.
loading
USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.
Laurila, Pirkka-Pekka; Soronen, Jarkko; Kooijman, Sander; Forsström, Saara; Boon, Mariëtte R; Surakka, Ida; Kaiharju, Essi; Coomans, Claudia P; Van Den Berg, Sjoerd A A; Autio, Anu; Sarin, Antti-Pekka; Kettunen, Johannes; Tikkanen, Emmi; Manninen, Tuula; Metso, Jari; Silvennoinen, Reija; Merikanto, Krista; Ruuth, Maija; Perttilä, Julia; Mäkelä, Anne; Isomi, Ayaka; Tuomainen, Anita M; Tikka, Anna; Ramadan, Usama Abo; Seppälä, Ilkka; Lehtimäki, Terho; Eriksson, Johan; Havulinna, Aki; Jula, Antti; Karhunen, Pekka J; Salomaa, Veikko; Perola, Markus; Ehnholm, Christian; Lee-Rueckert, Miriam; Van Eck, Miranda; Roivainen, Anne; Taskinen, Marja-Riitta; Peltonen, Leena; Mervaala, Eero; Jalanko, Anu; Hohtola, Esa; Olkkonen, Vesa M; Ripatti, Samuli; Kovanen, Petri T; Rensen, Patrick C N; Suomalainen, Anu; Jauhiainen, Matti.
Afiliação
  • Laurila PP; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland. Department of Medical Genetics, University of Helsinki, Helsinki FI-00014, Finland. Institute for Molecular Medicine Finland, FIMM, Helsinki FI-00251, Finland. pirkka-pekka.laurila@thl.fi matti.jauhi
  • Soronen J; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland. Institute for Molecular Medicine Finland, FIMM, Helsinki FI-00251, Finland. Minerva Foundation Institute for Medical Research, Helsinki FI-00290, Finland.
  • Kooijman S; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden 2333 ZA, Netherlands. Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  • Forsström S; Molecular Neurology, Research Programs Unit, University of Helsinki, Helsinki FI-00014, Finland.
  • Boon MR; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden 2333 ZA, Netherlands. Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  • Surakka I; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland. Institute for Molecular Medicine Finland, FIMM, Helsinki FI-00251, Finland.
  • Kaiharju E; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland.
  • Coomans CP; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden 2333 ZA, Netherlands. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  • Van Den Berg SA; Department of Human Genetics, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  • Autio A; Turku PET Centre, University of Turku and Turku University Hospital, Turku FI-20520, Finland.
  • Sarin AP; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland. Institute for Molecular Medicine Finland, FIMM, Helsinki FI-00251, Finland.
  • Kettunen J; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland. Institute for Molecular Medicine Finland, FIMM, Helsinki FI-00251, Finland. Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu FI-90014, Finla
  • Tikkanen E; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland. Institute for Molecular Medicine Finland, FIMM, Helsinki FI-00251, Finland. Hjelt Institute, University of Helsinki, Helsinki FI-00014, Finland.
  • Manninen T; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland. Molecular Neurology, Research Programs Unit, University of Helsinki, Helsinki FI-00014, Finland.
  • Metso J; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland.
  • Silvennoinen R; Wihuri Research Institute, Helsinki FI-00290, Finland.
  • Merikanto K; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland.
  • Ruuth M; Wihuri Research Institute, Helsinki FI-00290, Finland.
  • Perttilä J; Minerva Foundation Institute for Medical Research, Helsinki FI-00290, Finland.
  • Mäkelä A; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu FI-90014, Finland.
  • Isomi A; Hiroshima University, Hiroshima 730-0053, Japan.
  • Tuomainen AM; Institute of Dentistry, University of Helsinki, Helsinki FI-00014, Finland.
  • Tikka A; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland.
  • Ramadan UA; Experimental MRI Laboratory, Department of Neurology, Helsinki University Central Hospital, Helsinki FI-00290, Finland.
  • Seppälä I; Department of Clinical Chemistry, Fimlab Laboratories, and Tampere University School of Medicine, Tampere FI-33014, Finland.
  • Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, and Tampere University School of Medicine, Tampere FI-33014, Finland.
  • Eriksson J; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland. Folkhälsan Research Centre, Helsinki FI-00251, Finland. Unit of General Practice, Helsinki University Central Hospital, Helsinki FI-00290, Finland. Department of General Practice and Primary Health Care, Uni
  • Havulinna A; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
  • Jula A; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
  • Karhunen PJ; Department of Clinical Chemistry, Fimlab Laboratories, and Tampere University School of Medicine, Tampere FI-33014, Finland.
  • Salomaa V; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
  • Perola M; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland.
  • Ehnholm C; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland.
  • Lee-Rueckert M; Wihuri Research Institute, Helsinki FI-00290, Finland.
  • Van Eck M; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  • Roivainen A; Turku PET Centre, University of Turku and Turku University Hospital, Turku FI-20520, Finland. Turku Center for Disease Modeling, University of Turku, Turku FI-20520, Finland.
  • Taskinen MR; Diabetes and Obesity Research Program, University of Helsinki, Helsinki FI-00014, Finland.
  • Mervaala E; Institute of Biomedicine, University of Helsinki, Helsinki FI-00014, Finland.
  • Jalanko A; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland.
  • Hohtola E; Department of Genetics and Physiology, University of Oulu, Oulu FI-90014, Finland.
  • Olkkonen VM; Minerva Foundation Institute for Medical Research, Helsinki FI-00290, Finland.
  • Ripatti S; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland. Institute for Molecular Medicine Finland, FIMM, Helsinki FI-00251, Finland. Hjelt Institute, University of Helsinki, Helsinki FI-00014, Finland. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB
  • Kovanen PT; Wihuri Research Institute, Helsinki FI-00290, Finland.
  • Rensen PC; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden 2333 ZA, Netherlands. Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  • Suomalainen A; Molecular Neurology, Research Programs Unit, University of Helsinki, Helsinki FI-00014, Finland. Department of Neurology, Helsinki University Central Hospital, Helsinki FI-00290, Finland. Neuroscience Center, University of Helsinki, Helsinki FI-00014, Finland.
  • Jauhiainen M; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland. pirkka-pekka.laurila@thl.fi matti.jauhiainen@thl.fi.
Sci Transl Med ; 8(323): 323ra13, 2016 Jan 27.
Article em En | MEDLINE | ID: mdl-26819196
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Fatores Estimuladores Upstream Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Fatores Estimuladores Upstream Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article