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Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer.
Al-Ahmadie, Hikmat A; Iyer, Gopa; Lee, Byron H; Scott, Sasinya N; Mehra, Rohit; Bagrodia, Aditya; Jordan, Emmet J; Gao, Sizhi Paul; Ramirez, Ricardo; Cha, Eugene K; Desai, Neil B; Zabor, Emily C; Ostrovnaya, Irina; Gopalan, Anuradha; Chen, Ying-Bei; Fine, Samson W; Tickoo, Satish K; Gandhi, Anupama; Hreiki, Joseph; Viale, Agnès; Arcila, Maria E; Dalbagni, Guido; Rosenberg, Jonathan E; Bochner, Bernard H; Bajorin, Dean F; Berger, Michael F; Reuter, Victor E; Taylor, Barry S; Solit, David B.
Afiliação
  • Al-Ahmadie HA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Iyer G; Weill Cornell Medical College, Cornell University, New York, New York, USA.
  • Lee BH; Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Scott SN; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Mehra R; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Bagrodia A; Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan, USA.
  • Jordan EJ; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Gao SP; Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Ramirez R; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Cha EK; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Desai NB; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York, USA.
  • Zabor EC; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Ostrovnaya I; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Gopalan A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Chen YB; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Fine SW; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Tickoo SK; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Gandhi A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Hreiki J; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Viale A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Arcila ME; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Dalbagni G; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Rosenberg JE; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Bochner BH; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Bajorin DF; Weill Cornell Medical College, Cornell University, New York, New York, USA.
  • Berger MF; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Reuter VE; Weill Cornell Medical College, Cornell University, New York, New York, USA.
  • Taylor BS; Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Solit DB; Weill Cornell Medical College, Cornell University, New York, New York, USA.
Nat Genet ; 48(4): 356-8, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26901067
ABSTRACT
Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmocitoma / Neoplasias da Bexiga Urinária / Caderinas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmocitoma / Neoplasias da Bexiga Urinária / Caderinas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article