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Disseminated Metastatic Tissue Calcification After Orthotopic Liver Transplantation: A Case Report.
Deguchi, K; Ueno, T; Matsuura, R; Yamanaka, H; Nara, K; Uehara, S; Tazuke, Y; Bessho, K; Okuyama, H.
Afiliação
  • Deguchi K; Department of Pediatric Surgery, Osaka University, Postgraduate School of Medicine, Osaka, Japan.
  • Ueno T; Department of Pediatric Surgery, Osaka University, Postgraduate School of Medicine, Osaka, Japan. Electronic address: ueno@pedsurg.med.osaka-u.ac.jp.
  • Matsuura R; Department of Pediatric Surgery, Osaka University, Postgraduate School of Medicine, Osaka, Japan.
  • Yamanaka H; Department of Pediatric Surgery, Osaka University, Postgraduate School of Medicine, Osaka, Japan.
  • Nara K; Department of Pediatric Surgery, Osaka University, Postgraduate School of Medicine, Osaka, Japan.
  • Uehara S; Department of Pediatric Surgery, Osaka University, Postgraduate School of Medicine, Osaka, Japan.
  • Tazuke Y; Department of Pediatric Surgery, Osaka University, Postgraduate School of Medicine, Osaka, Japan.
  • Bessho K; Department of Pediatrics, Osaka University, Postgraduate School of Medicine, Osaka, Japan.
  • Okuyama H; Department of Pediatric Surgery, Osaka University, Postgraduate School of Medicine, Osaka, Japan.
Transplant Proc ; 48(1): 251-4, 2016.
Article em En | MEDLINE | ID: mdl-26915877
ABSTRACT

BACKGROUND:

Hypercalcemia has been observed in patients after liver transplantation. However, it is rare that the hypercalcemia induced disseminated tissue calcification and heart failure. CASE REPORT We report a rare case of heart failure caused by disseminated metastatic tissue calcification that involved extensive progressive myocardial calcification after liver transplantation. A 20-year-old man with end-stage liver disease due to biliary atresia underwent ABO-incompatible living donor liver transplantation. After successful transplantation, he suffered from antibody-mediated rejection. Subsequently, ABO-matched cadaveric liver retransplantation was successfully performed. Hypercalcemia developed gradually following the second transplantation. His serum calcium level increased to 18.3 mg/dL with sudden onset of ventricular tachycardia. Although he was resuscitated with a cardiopulmonary support device, he died of heart and liver failure. Histopathologic examination revealed systemic disseminated metastatic tissue calcification, including massive myocardial calcification.

CONCLUSION:

Progressive worsening of hypercalcemia resulted in disseminated metastatic tissue calcification and massive metastatic myocardial calcification, which led to heart failure after liver transplantation. Because hypercalcemia after liver transplantation can cause fatal tissue calcification, early intervention for hypercalcemia should be considered.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calcinose / Transplante de Fígado / Falência Hepática / Hipercalcemia / Cardiomiopatias Tipo de estudo: Etiology_studies Limite: Adult / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calcinose / Transplante de Fígado / Falência Hepática / Hipercalcemia / Cardiomiopatias Tipo de estudo: Etiology_studies Limite: Adult / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article