UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness.
Cell
; 164(5): 872-83, 2016 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-26919426
ABSTRACT
The ventromedial nucleus of the hypothalamus (VMH) plays a critical role in regulating systemic glucose homeostasis. How neurons in this brain area adapt to the changing metabolic environment to regulate circulating glucose levels is ill defined. Here, we show that glucose load results in mitochondrial fission and reduced reactive oxygen species in VMH neurons mediated by dynamin-related peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2). Probed by genetic manipulations and chemical-genetic control of VMH neuronal circuitry, we unmasked that this mitochondrial adaptation determines the size of the pool of glucose-excited neurons in the VMH and that this process regulates systemic glucose homeostasis. Thus, our data unmasked a critical cellular biological process controlled by mitochondrial dynamics in VMH regulation of systemic glucose homeostasis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Núcleo Hipotalâmico Ventromedial
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Núcleo Celular
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Proteínas Mitocondriais
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Dinâmica Mitocondrial
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Glucose
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Canais Iônicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article