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Generation and deposition of Aß43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
Kretner, Benedikt; Trambauer, Johannes; Fukumori, Akio; Mielke, Janina; Kuhn, Peer-Hendrik; Kremmer, Elisabeth; Giese, Armin; Lichtenthaler, Stefan F; Haass, Christian; Arzberger, Thomas; Steiner, Harald.
Afiliação
  • Kretner B; Biomedical Center, Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.
  • Trambauer J; Biomedical Center, Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Fukumori A; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.
  • Mielke J; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Kuhn PH; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany Neuroproteomics, Klinikum rechts der Isar and Institute for Advanced Study, Technische Universität München, Munich, Germany.
  • Kremmer E; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany Institute of Molecular Immunology, Helmholtz Zentrum München, Munich, Germany.
  • Giese A; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Lichtenthaler SF; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany Neuroproteomics, Klinikum rechts der Isar and Institute for Advanced Study, Technische Universität München, Munich, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Haass C; Biomedical Center, Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Arzberger T; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Steiner H; Biomedical Center, Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany harald.steiner@med.uni-muenchen.de.
EMBO Mol Med ; 8(5): 458-65, 2016 05.
Article em En | MEDLINE | ID: mdl-26988102
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Proteínas Mutantes / Presenilina-1 / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Proteínas Mutantes / Presenilina-1 / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article