Disruption of estrogen homeostasis as a mechanism for uterine toxicity in Wistar Han rats treated with tetrabromobisphenol A.

Sanders, J Michael; Coulter, Sherry J; Knudsen, Gabriel A; Dunnick, June K; Kissling, Grace E; Birnbaum, Linda S

Sanders, J Michael; Coulter, Sherry J; Knudsen, Gabriel A; Dunnick, June K; Kissling, Grace E; Birnbaum, Linda S.

Afiliação

Sanders JM; Laboratory of Toxicology and Toxicokinetics, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States. Electronic address: sander10@mail.nih.gov.
Coulter SJ; Laboratory of Toxicology and Toxicokinetics, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.
Knudsen GA; Laboratory of Toxicology and Toxicokinetics, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.
Dunnick JK; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.
Kissling GE; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.
Birnbaum LS; Laboratory of Toxicology and Toxicokinetics, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.

Toxicol Appl Pharmacol ; 298: 31-9, 2016 May 01.

Article em En | MEDLINE | ID: mdl-26988606

Assuntos

Poluentes Ambientais/toxicidade; Estrogênios/metabolismo; Expressão Gênica/efeitos dos fármacos; Homeostase/efeitos dos fármacos; Bifenil Polibromatos/toxicidade; Útero/efeitos dos fármacos; Animais; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Receptor alfa de Estrogênio/genética; Receptor beta de Estrogênio/genética; Estrogênios/sangue; Feminino; Homeostase/genética; Fígado/efeitos dos fármacos; Fígado/metabolismo; Fígado/patologia; Ratos Wistar; Útero/metabolismo; Útero/patologia

Palavras-chave

Estrogen homeostasis; Gene expression; Rats; TBBPA; Tetrabromobisphenol A; Uterine toxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Útero / Expressão Gênica / Bifenil Polibromatos / Poluentes Ambientais / Estrogênios / Homeostase Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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