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Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors.
Greshock, Thomas J; Sanders, John M; Drolet, Robert E; Rajapakse, Hemaka A; Chang, Ronald K; Kim, Boyoung; Rada, Vanessa L; Tiscia, Heather E; Su, Hua; Lai, Ming-Tain; Sur, Sylvie M; Sanchez, Rosa I; Bilodeau, Mark T; Renger, John J; Kern, Jonathan T; McCauley, John A.
Afiliação
  • Greshock TJ; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, United States. Electronic address: thomas_greshock@merck.com.
  • Sanders JM; Department of Chemistry Modeling and Informatics, Merck Research Laboratories, West Point, PA 19486, United States. Electronic address: john_sanders@merck.com.
  • Drolet RE; Department of Neuroscience Research, Merck Research Laboratories, West Point, PA 19486, United States.
  • Rajapakse HA; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Chang RK; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Kim B; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Rada VL; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Tiscia HE; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Su H; Department of Structural Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Lai MT; Department of In Vitro Pharmacology, Merck Research Laboratories, West Point, PA 19486, United States.
  • Sur SM; Department of In Vitro Pharmacology, Merck Research Laboratories, West Point, PA 19486, United States.
  • Sanchez RI; Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, United States.
  • Bilodeau MT; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
  • Renger JJ; Department of Neuroscience Research, Merck Research Laboratories, West Point, PA 19486, United States.
  • Kern JT; Department of Neuroscience Research, Merck Research Laboratories, West Point, PA 19486, United States.
  • McCauley JA; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, United States.
Bioorg Med Chem Lett ; 26(11): 2631-5, 2016 06 01.
Article em En | MEDLINE | ID: mdl-27106707
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Inibidores de Proteínas Quinases / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Inibidores de Proteínas Quinases / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article