S6K1ing to ResTOR Adipogenesis with Polycomb.

Juan, Aster H; Sartorelli, Vittorio

Juan, Aster H; Sartorelli, Vittorio.

Afiliação

Juan AH; Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA.
Sartorelli V; Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: sartorev@mail.nih.gov.

Mol Cell ; 62(3): 325-326, 2016 05 05.

Article em En | MEDLINE | ID: mdl-27153531

RESUMO

Signal-directed chromatin recruitment of mammalian Polycomb complexes is a fundamental component of epigenetic regulation. In this issue, Yi et al. (2016) reveal how mTORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic regulatory regions to repress expression of anti-adipogenic developmental regulators.

Assuntos

Adipogenia; Epigênese Genética; Animais; Cromatina; Proteínas de Drosophila/genética; Proteínas do Grupo Polycomb/genética; Serina-Treonina Quinases TOR/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epigênese Genética / Adipogenia Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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