The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.

Warrilow, Andrew G S; Parker, Josie E; Price, Claire L; Nes, W David; Garvey, Edward P; Hoekstra, William J; Schotzinger, Robert J; Kelly, Diane E; Kelly, Steven L

Warrilow, Andrew G S; Parker, Josie E; Price, Claire L; Nes, W David; Garvey, Edward P; Hoekstra, William J; Schotzinger, Robert J; Kelly, Diane E; Kelly, Steven L.

Afiliação

Warrilow AG; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea, Wales, United Kingdom.
Parker JE; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea, Wales, United Kingdom.
Price CL; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea, Wales, United Kingdom.
Nes WD; Center for Chemical Biology, Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Garvey EP; Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
Hoekstra WJ; Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
Schotzinger RJ; Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
Kelly DE; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea, Wales, United Kingdom.
Kelly SL; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea, Wales, United Kingdom s.l.kelly@swansea.ac.uk.

Antimicrob Agents Chemother ; 60(8): 4530-8, 2016 08.

Article em En | MEDLINE | ID: mdl-27161631

Assuntos

Antifúngicos/farmacologia; Cryptococcus/efeitos dos fármacos; Piridinas/efeitos adversos; Piridinas/farmacologia; Esterol 14-Desmetilase/metabolismo; Tetrazóis/efeitos adversos; Tetrazóis/farmacologia; Antifúngicos/efeitos adversos; Clotrimazol/efeitos adversos; Clotrimazol/farmacologia; Cryptococcus/metabolismo; Ativação Enzimática/efeitos dos fármacos; Ergosterol/metabolismo; Fluconazol/efeitos adversos; Fluconazol/farmacologia; Humanos; Itraconazol/efeitos adversos; Itraconazol/farmacologia; Cetoconazol/efeitos adversos; Cetoconazol/farmacologia; Lanosterol/análogos & derivados; Lanosterol/metabolismo; Voriconazol/efeitos adversos; Voriconazol/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Tetrazóis / Cryptococcus / Esterol 14-Desmetilase / Antifúngicos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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