Direct Diastereo- and Enantioselective Vinylogous Michael Additions of Linear Enones.
Org Lett
; 18(11): 2628-31, 2016 06 03.
Article
em En
| MEDLINE
| ID: mdl-27186662
ABSTRACT
A direct vinylogous Michael addition using linear vinylogous Michael donors has been developed. Notably, even γ-substituted Michael donors cleanly afforded γ-alkylated products in high yield and ee by this method. Moreover, control experiments revealed that, for these and related linear vinylogous Michael donors, the size of the Michael acceptor strongly influences whether α- or γ-alkylation occurs, not simply blocking effects of cocatalysts as suggested previously.
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MEDLINE
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En
Ano de publicação:
2016
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Article