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Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy.
Sawant-Basak, Aarti; Chen, Laigao; Shaffer, Christopher L; Palumbo, Donna; Schmidt, Anne; Tseng, Elaine; Spracklin, Douglas K; Gallezot, Jean-Dominique; Labaree, David; Nabulsi, Nabeel; Huang, Yiyun; Carson, Richard E; McCarthy, Timothy.
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  • Sawant-Basak A; a Departments of Pharmacokinetics , Dynamics, and Metabolism, Pfizer Inc. , Cambridge , MA , USA.
  • Chen L; b Clinical & Translational Imaging, Pfizer Inc. , Cambridge , MA , USA.
  • Shaffer CL; c Neuroscience and Pain Research Unit, Pfizer Inc. , Cambridge , MA , USA.
  • Palumbo D; d Worldwide Research and Development, Pfizer Inc. , Cambridge , MA , USA , and.
  • Schmidt A; a Departments of Pharmacokinetics , Dynamics, and Metabolism, Pfizer Inc. , Cambridge , MA , USA.
  • Tseng E; a Departments of Pharmacokinetics , Dynamics, and Metabolism, Pfizer Inc. , Cambridge , MA , USA.
  • Spracklin DK; a Departments of Pharmacokinetics , Dynamics, and Metabolism, Pfizer Inc. , Cambridge , MA , USA.
  • Gallezot JD; e Department of Diagnostic Radiology , Yale University , New Haven , CT , USA.
  • Labaree D; e Department of Diagnostic Radiology , Yale University , New Haven , CT , USA.
  • Nabulsi N; e Department of Diagnostic Radiology , Yale University , New Haven , CT , USA.
  • Huang Y; e Department of Diagnostic Radiology , Yale University , New Haven , CT , USA.
  • Carson RE; e Department of Diagnostic Radiology , Yale University , New Haven , CT , USA.
  • McCarthy T; b Clinical & Translational Imaging, Pfizer Inc. , Cambridge , MA , USA.
Xenobiotica ; 47(2): 119-126, 2017 Feb.
Article em En | MEDLINE | ID: mdl-27353353
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinas / Ciclobutanos / Antagonistas dos Receptores Histamínicos H3 Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinas / Ciclobutanos / Antagonistas dos Receptores Histamínicos H3 Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article