Engineering Large Animal Species to Model Human Diseases.
Curr Protoc Hum Genet
; 90: 15.9.1-15.9.14, 2016 07 01.
Article
em En
| MEDLINE
| ID: mdl-27367161
ABSTRACT
Animal models are an important resource for studying human diseases. Genetically engineered mice are the most commonly used species and have made significant contributions to our understanding of basic biology, disease mechanisms, and drug development. However, they often fail to recreate important aspects of human diseases and thus can have limited utility as translational research tools. Developing disease models in species more similar to humans may provide a better setting in which to study disease pathogenesis and test new treatments. This unit provides an overview of the history of genetically engineered large animals and the techniques that have made their development possible. Factors to consider when planning a large animal model, including choice of species, type of modification and methodology, characterization, production methods, and regulatory compliance, are also covered. © 2016 by John Wiley & Sons, Inc.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Engenharia Genética
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Organismos Geneticamente Modificados
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Tamanho Corporal
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Modelos Animais de Doenças
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article