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5-hydroxytryptamine and Lyme disease. Opportunity for a novel therapy to reduce the cerebellar tremor?
Maximov, G K; Maximov, K G; Chokoeva, A A; Lotti, T; Wollina, U; Patterson, J W; Guarneri, C; Tana, C; Fioranelli, M; Roccia, M G; Kanazawa, N; Tchernev, G.
Afiliação
  • Maximov GK; Department “Medicinal Information and Non-interventional studies”, Bulgarian Drug Agency, Sofia, Bulgaria.
  • Maximov KG; Neuromed Center for Neurology and Neurosurgery, Military Medical Academy, Sofia, Bulgaria.
  • Chokoeva AA; “Onkoderma”- Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria; Department of Dermatology and Venereology, Medical University of Plovdiv, Medical Faculty, Plovdiv, Bulgaria.
  • Lotti T; Department of Dermatology, University of Rome “G. Marconi” Rome, Italy.
  • Wollina U; Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
  • Patterson JW; University of Virginia Health System, Department of Pathology, Charlottesville, VA USA.
  • Guarneri C; Department of Clinical and Experimental Medicine, Section of Dermatology, University Hospital of Messina, Messina, Italy.
  • Tana C; Internal Medicine Unit, Guastalla Hospital, AUSL Reggio Emilia, Reggio Emilia, Italy.
  • Fioranelli M; History Department, G.Marconi University, Rome, Italy.
  • Roccia MG; University B.I.S. Group of Institutions, Punjab Technical University, Punjab, India.
  • Kanazawa N; Department of Dermatology, Wakayama Medical University, Wakayama, Japan.
  • Tchernev G; Medical Institute of Ministry of Interior (MVR-Sofia), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
J Biol Regul Homeost Agents ; 30(2 Suppl 2): 7-12, 2016.
Article em En | MEDLINE | ID: mdl-27373127
ABSTRACT
Lyme boreliosis is caused by the spirochete Borrelia burdorferi, which is transmitted by ticks. A 59 year-old woman developed pyrexia, strong headaches, ataxia, dysarthria and tremor of the limbs after a tick bite. She was unable to work and eat on her own. She was hospitalized three times and diagnosed with cerebellar intention tremor, cerebellar ataxia, dysarthria, bilateral horizontal gaze paralysis and a central lesion of the left facial nerve. There were no pyramidal, sensory or psychiatric disturbances. The brain MRI showed multifocal leucoencephalopathy with many hyperintense areas in both hemispheres, as well as in the left superior pedunculus cerebellaris. Diagnosis was confirmed by serologic examination. Treatment with cephtriaxone, doxycycline, methylprednisolone, cephixime and ciprofloxacine was administered without effect on the tremor, ataxia and horizontal gaze paralysis. Treatment was then administered with 5-hydroxytriptamine (5-HT) in increased doses. The result of the three-month treatment with 5-HT was a gradual diminution of the tremor and the ataxia and an increase in the ability to eat, walk and work independently.
Assuntos
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Base de dados: MEDLINE Assunto principal: Tremor / Doença de Lyme / Serotonina Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Tremor / Doença de Lyme / Serotonina Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article