Reduced paucimannosidic N-glycan formation by suppression of a specific ß-hexosaminidase from Nicotiana benthamiana.

Shin, Yun-Ji; Castilho, Alexandra; Dicker, Martina; Sádio, Flavio; Vavra, Ulrike; Grünwald-Gruber, Clemens; Kwon, Tae-Ho; Altmann, Friedrich; Steinkellner, Herta; Strasser, Richard

Shin, Yun-Ji; Castilho, Alexandra; Dicker, Martina; Sádio, Flavio; Vavra, Ulrike; Grünwald-Gruber, Clemens; Kwon, Tae-Ho; Altmann, Friedrich; Steinkellner, Herta; Strasser, Richard.

Afiliação

Shin YJ; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Castilho A; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Dicker M; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Sádio F; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Vavra U; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Grünwald-Gruber C; Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
Kwon TH; NBM Inc., Wanju-gun, Jeollabuk-do, Korea.
Altmann F; Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
Steinkellner H; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Strasser R; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.

Plant Biotechnol J ; 15(2): 197-206, 2017 02.

Article em En | MEDLINE | ID: mdl-27421111

Assuntos

Nicotiana/metabolismo; Polissacarídeos/biossíntese; beta-N-Acetil-Hexosaminidases/antagonistas & inibidores; Arabidopsis/genética; Arabidopsis/metabolismo; Sequência de Bases; Membrana Celular/metabolismo; Genes de Plantas; Glicosilação; Folhas de Planta/metabolismo; Proteínas de Plantas/genética; Proteínas de Plantas/metabolismo; Plantas Geneticamente Modificadas/metabolismo; Polissacarídeos/metabolismo; Proteínas Recombinantes/biossíntese; Proteínas Recombinantes/metabolismo; Nicotiana/enzimologia; Nicotiana/genética; Vacúolos/metabolismo

Palavras-chave

Nicotiana benthamiana; N-glycosylation; glyco-engineering; plant-made pharmaceuticals; α1-antitrypsin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polissacarídeos / Nicotiana / Beta-N-Acetil-Hexosaminidases Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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