The synthesis of substituted phosphathiahelicenes via regioselective bromination of a preformed helical scaffold: a new approach to modular ligands for enantioselective gold-catalysis.
Chem Commun (Camb)
; 52(73): 10984-7, 2016 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-27534612
ABSTRACT
Substituted phosphathiahelicenes have been prepared via a straightforward two-step procedure involving the regioselective bromination of a preformed helical scaffold, followed by palladium catalyzed coupling reactions. The new helicenes have been used as ligands in gold(i)-catalyzed [4+2] cyclizations of 1,6-enynes. The resulting dihydro-cyclopenta[b]naphthalene derivative was obtained in excellent yields and with up to 91% ee.
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MEDLINE
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En
Ano de publicação:
2016
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Article