Assessment of physical fatigability and fatigue perception in myasthenia gravis.
Muscle Nerve
; 55(5): 657-663, 2017 05.
Article
em En
| MEDLINE
| ID: mdl-27543741
ABSTRACT
INTRODUCTION:
Fatigue includes both performance fatigability and fatigue perception.METHODS:
In 32 stable patients with generalized myasthenia gravis (MG) and 17 controls, time-dependent physical performance was assessed by the arm movement test (AMT) and 6-minute walk test (6MWT). MG patients presented with low quantitative MG scores (mean 0.5, SD 0.5) and without pathologic decrement. Fatigability was based on calculation of linear trend (LT) reflecting dynamic performance within subsequent constant time intervals. Perception of physical fatigue was analyzed using fatigue questionnaires.RESULTS:
MG patients showed a negative LT in both AMT and 6MWT, significantly differing from stable performance in controls. LT inversely correlated with elevation of acetylcholine receptor antibodies (r = -0.59, P < 0.005) but not with quantitative MG score and fatigue perception.CONCLUSIONS:
LT allows quantification of fatigability as an objective measurement of decline in individual performance, even in patients without obvious neuromuscular deficits in routine testing. The missing correlation of experienced fatigue supports the multidimensional fatigue model. Muscle Nerve 55 657-663, 2017.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Percepção
/
Resistência Física
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Fadiga Muscular
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Fadiga
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Miastenia Gravis
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article